AntlerA Norrin/Wnt-agonist antibody through a strategic partnership with EyeBio enters clinical trials for treatment of retinopathies.
AntlerA previously reported the development of a Norrin/Wnt-mimetic for treatment of leaky blood vessels in the eye.
“We are pleased to support EyeBio in the development and advancement of EYE103, a Norrin/Wnt-mimetic, into the clinic. Built based on AntlerA’s ANT-Pharm platform the tetravalent antibody molecule binds specifically to FZD4/LRP5 receptors leading to Wnt-signaling and restoration of blood vessels integrity in the eye.” said Dr. Sekar Seshagiri, CEO, AntlerA Therapeutics. He further added “This is a first-in class molecule for treatment of diabetic retinopathy and several pediatric retinal diseases such as FEVR/Norrie, Coats, and ROP”
